Organic Synthesis: The Disconnection Approach


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With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules.

‎Workbook for Organic Synthesis: The Disconnection Approach on Apple Books

Reversing this process gives a synthetic route to the target molecule from simpler starting materials. Les mer. Om boka One approach to organic synthesis is retrosynthetic analysis. This "disconnection" approach to synthesis is now a fundamental part of every organic synthesis course.

Retrosynthesis (Part 1): Choosing a Disconnection

Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion.


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The examples extend the student's experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work.

Reasons for wishing to synthesise each compound are given.

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Each precursor material is examined using the same method. This procedure is repeated until simple or commercially available structures are reached. Corey formalized this concept in his book The Logic of Chemical Synthesis. The power of retrosynthetic analysis becomes evident in the design of a synthesis.

The goal of retrosynthetic analysis is structural simplification.

Retrosynthetic analysis

Often, a synthesis will have more than one possible synthetic route. Retrosynthesis is well suited for discovering different synthetic routes and comparing them in a logical and straightforward fashion. In that case, no further exploration of that compound would be required. If that compound exists, it can be a jumping point for further steps developed to reach a synthesis.

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In planning the synthesis of phenylacetic acid , two synthons are identified. Of course, both synthons do not exist per se; synthetic equivalents corresponding to the synthons are reacted to produce the desired product. In fact, phenylacetic acid has been synthesized from benzyl cyanide , [5] itself prepared by the analogous reaction of benzyl chloride with sodium cyanide. Manipulation of functional groups can lead to significant reductions in molecular complexity.

Numerous chemical targets have distinct stereochemical demands.

Workbook for Organic Synthesis: The Disconnection Approach

Stereochemical transformations such as the Claisen rearrangement and Mitsunobu reaction can remove or transfer the desired chirality thus simplifying the target. Directing a synthesis toward a desirable intermediate can greatly narrow the focus of an analysis.

This allows bidirectional search techniques. The application of transformations to retrosynthetic analysis can lead to powerful reductions in molecular complexity.


  • ‎Workbook for Organic Synthesis: The Disconnection Approach on Apple Books.
  • Workbook for Organic Synthesis: The Disconnection Approach.
  • Sidonius: Poems. Letters, Books 1-2 (Loeb Classical Library No. 296).
  • Workbook for Organic Synthesis: The Disconnection Approach.
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Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach
Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach
Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach
Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach
Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach
Organic Synthesis: The Disconnection Approach Organic Synthesis: The Disconnection Approach

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